An ontologically founded architecture for information systems in clinical and epidemiological research

This paper presents an ontologically founded basic architecture for information systems, which are intended to capture, represent, and maintain metadata for various domains of clinical and epidemiological research. Clinical trials exhibit an important basis for clinical research, and the accurate specification of metadata and their documentation and application in clinical and epidemiological study projects represents a significant expense in the project preparation and has a relevant impact on the value and quality of these studies

Die Bibliothek als Erfolgsfaktor - 10 Jahre danach

Im Jahr 2022 feiert die Universitätsbibliothek Bochum ihr 60. Jubiläum. Die UB Bochum ist auf dem Campus der Ruhr-Universität Bochum neben ihrer Rolle als professionelle Dienstleisterin für Studium, Lehre und Forschung längst ein attraktiver Lern- und Begegnungsort, geographisch zentral und in Sachen Digitalisierung sowie Vernetzung und Kooperationen zukunftsweisend

Grand challenges for catalysis in the Science and Technology Roadmap on Catalysis for Europe: Moving ahead catalysis for a sustainable future

This perspective discusses the general concepts that will guide future catalysis and related grand-challenges, based on The European Roadmap on Science and Technology of Catalysis prepared by the European Cluster on Catalysis. To adress the changing scenario in refinery and chemical production, and move to a low-carbon sustrainable future, the distinguishing elements of three grand-challenges for catalysis are discussed here: 1) catalysis to address the evolving energy and chemical scenario, 2) catalysis for a cleaner and sustainable future, and 3) addressing catalysis complexity, the latter being organized in three sub-topics: advanced design of novel catalysts, understanding catalysts from molecular to material scale, and expanding catalysis concepts

Experimental Porcine Toxoplasma gondii Infection as a Representative Model for Human Toxoplasmosis

Porcine infections are currently not the state-of-the-art model to study human diseases. Nevertheless, the course of human and porcine toxoplasmosis is much more comparable than that of human and murine toxoplasmosis. For example, severity of infection, transplacental transmission, and interferon-gamma-induced antiparasitic effector mechanisms are similar in pigs and humans. In addition, the severe immunosuppression during acute infection described in mice does not occur in the experimentally infected ones. Thus, we hypothesise that porcine Toxoplasma gondii infection data are more representative for human toxoplasmosis. We therefore suggest that the animal model chosen must be critically evaluated for its assignability to human diseases

Mitochondrial Ccs1 contains a structural disulfide bond crucial for the import of this unconventional substrate by the disulfide relay system

The Mia40/Erv1 disulfide relay system forms a structural disulfide bond in Ccs1, an unconventional substrate of this system. Thereby it promotes import of Ccs1 into mitochondria and controls its cellular distribution. Thus this system is unexpectedly able to form single disulfide bonds in complex multidomain proteins

Confirmation of the topology of the Wendelstein 7-X magnetic field to better than 1:100,000

Fusion energy research has in the past 40 years focused primarily on the tokamak concept, but recent advances in plasma theory and computational power have led to renewed interest in stellarators. The largest and most sophisticated stellarator in the world, Wendelstein 7-X (W7-X), has just started operation, with the aim to show that the earlier weaknesses of this concept have been addressed successfully, and that the intrinsic advantages of the concept persist, also at plasma parameters approaching those of a future fusion power plant. Here we show the first physics results, obtained before plasma operation: that the carefully tailored topology of nested magnetic surfaces needed for good confinement is realized, and that the measured deviations are smaller than one part in 100,000. This is a significant step forward in stellarator research, since it shows that the complicated and delicate magnetic topology can be created and verified with the required accuracy